Asst. Prof. Dr. Siriwan Ongchai
Thailand Excellence Center for Tissue Engineering, Department of Biochemistry,
Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., and
Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.

Osteoarthritis (OA) is the most common form of arthritis. It results from an imbalance between predominantly chondrocyte-controlled anabolic and catabolic processes, and is characterized by progressive degradation of the components of the extracellular matrix (ECM) of the articular cartilage, associated with secondary inflammatory factors.

The effect of xanthones from mangosteen on the cartilage degradation in vitro and human chondrocyte culture was investigated. GM-1 was found to be the most active, comparable to or even better than the drugs presently prescribed for osteoarthritis. The detail of this findings together with the molecular mechanism and mode of action will be presented.

  • Lab Data of BIM Capsule and BIM Mangosteen Juice
  • Antioxidation and antimalarial activities of xanthones from mangosteen
  • Anti-bacterial activities of xanthones from mangosteen
  • Anti-inflammation of xanthones from mangosteen
  • Molecular investigation on anti-cartilage degradation by xanthones from mangosteen
  • Mangosteen products: from the lab bench to the world market
  • Operation BIM : Presented in the 34th CONGRESS on SCIENCE and TECHNOLOGY of THAILAND (STT 34),
    30 October, 2008