THAI | ENG  
 
 
   
 
 
 
 
  Assoc. Prof. Dr. Wilawan Mahabusarakam
Department of Chemistry, Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.
Dr. Metta Ongsakul
Department of Microbiology, Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.
นงพร โตวัฒนะ
Department of Biochemistry, Faculty of Science, Prince of Songkla University, Hatyai, Songkhla, Thailand
ประพนธ์ วิไลรัตน์
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
 
 

In cardiovascular disease, it has been generally accepted that oxidative modification of LDL plays a critical role in atherosclerosis. Therefore, antioxidants able to interfere with lipid peroxidation may be beneficial in reducing atherogenic process. GM-1, a major xanthone in the fruit hulls of Garcinia mangostana, was shown for the first time to be a free radical scavenger protecting the LDL from oxidative damage in vitro in 1995. Some years later, a series of GM-1 derivatives were prepared and then tested for their activities on LDL oxidation. Some of them exhibited more profound effects than GM-1 itself. Therefore, some structural modifications of GM-1 are capable of enhancing its antioxidant activity.

GM-1 and its derivatives have also been shown to be antiplasmodial, antioxidant, and inhibiting eukaryote protein kinases and cyclic nucleotide-binding phosphatase.

 
 
 
 
 
 
 
  • Lab Data of BIM Capsule and BIM Mangosteen Juice
  • Antioxidation and antimalarial activities of xanthones from mangosteen
  • Anti-bacterial activities of xanthones from mangosteen
  • Anti-inflammation of xanthones from mangosteen
  • Molecular investigation on anti-cartilage degradation by xanthones from mangosteen
  • Mangosteen products: from the lab bench to the world market
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