Conclusion
After activation, T helper cells (Th cells or CD4+ lymphocytes) differentiate into Th1 or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses.  Th1 cells are described to be responsible for mediating cellular immunity, whereas the Th2 cells mediate humoral immunity and associate with hypersenisitivity. Recently, a new Th subset, Th17, was discovered and demonstrated to be involved in body inflammatory responses.

The operation BIM product, developed by the Asian Phytoceuticals Public Co. Ltd., is the mixture of the highly nutritious fruit and grain ingredients. The operation BIM was demonstrated to be safe and absent of side-effects and has been registered with the Office of Food and Drug Administration as dietary supplements. The effectiveness of the operation BIM product has been reported by consumers suffering from various diseases including ulcers, chronic wounds in the stomach, rheumatoid arthritis, deteriorated kneecap, diabetes, liver failure, Parkinson’s disease, chronic infection, psoriasis and even the last stage cancer. They all agreed that their quality of life was improved by the operation BIM product. It was suggested that the operation BIM product may modulate immune responses, however, the detail mechanisms has not been elucidated. In the present study, we demonstrated that the operation BIM product can activate in vivo the Th1 and Th17 lymphocyte subpopulations. As both Th1 and Th17 cells produce cytokines that play a major role in cell-mediated immunity and inflammatory responses. We hypothesize that the operation BIM product activates and generates the Th1/Th17 polarization which then adjusts the balance immune response into the benefit arms for body defense.